How is LCIS?

➢ Uniform appearance. ➢ The cells are monomorphic, have bland, round nuclei, and are found in loosely cohesive clusters within the lobules ➢ LCIS is virtually always an incidental finding because, unlike DCIS, it is only rarely associated with calcifications. ➢ Approximately one-third of women with LCIS eventually develop invasive carcinoma. ➢ Unlike DCIS, invasive carcinomas following a diagnosis of LCIS may arise in either breast : 2/3 in the same breast and 1/3 in the contralateral breast. ➢ LCIS is both a marker of an increased risk of carcinoma in both breasts and a direct precursor of some cancers. ➢ Current treatment options include close clinical and radiologic follow-up, chemoprevention with tamoxifen or, less commonly, bilateral prophylactic mastectomy