What are carcinomas w/medullary features?

➢ special type of triple-negative cancer comprising about 5% of all breast cancers. These carcinomas typically grow as rounded masses ➢ that can be difficult to distinguish from benign tumors on imaging ➢ They consist of sheets of large anaplastic cells associated with pronounced lymphocytic infiltrates composed predominantly of T cells ➢ The presence of lymphocytes is associated with a favorable prognosis, at least in part due to a better response to chemotherapy compared to poorly differentiated carcinomas without lymphoid infiltrates. ➢ This type is seen frequently in women with germline BRCA1 mutations, but most women with these carcinomas are not carriers.