How is seminoma morphology?

➢ Large, uniform cells with distinct cell borders, clear, glycogen-rich cytoplasm, round nuclei, and conspicuous nucleoli ➢ Small lobules with intervening fibrous septa ➢ Lymphocytic infiltrate usually is present ➢ Granulomatous reaction ➢ 15% of cases, syncytiotrophoblasts are present – (elevated serum HCG) ➢ Often remain confined to the testis for long periods and may reach considerable size before diagnosis ➢ Metastases most commonly are encountered in the iliac and paraaortic lymph nodes, particularly in the upper lumbar region ➢ Hematogenous metastases occur late ➢ Sensitive to radiation and chemotherapy ➢ Good prognosis