How is histologic dx of secondary bone tumors?

The histological diagnosis of a metastasis is based on: ➢ The origin of the malignant cells (epithelial / melanocytic, etc.) ➢ The expression of certain proteins and / or the secretion of certain substances by tumor cells, most often demonstrated by immunohistochemistry or histochemistry: Mucines, HR, Neuroendocrine secretory grains… ➢ The choice of the antibodies for an immunohistochemical study depends on the diagnostic hypotheses ➢ The diagnostic hypotheses are made On the morphological appearance of the tumor observed on the standard staining (HE) On clinical / biological and radiological information. ➢ The choice of Ab also depends on the possible therapeutic incidence.