How is tx of conventional osteosarcoma? dx features?

➢ The usual treatment includes neoadjuvant chemotherapy, followed by a surgical resection in block of the tumor: with wide surgical margins, leaving a layer of healthy tissue around the piece of resection ➢ an eventual chemotherapy after adjuvant will depends on the histological response of the tumor. ➢ Post-chemotherapy tumor necrosis is an essential element of the pathologist report of the resection piece, for the evaluation of the effectiveness of the chemotherapeutic treatment. ➢ The formation of osteoid matrix or mineralized bone by malignant tumor cells is diagnostic of osteosarcoma ➢ Fine, lacelike pattern of neoplastic bone produced by anaplastic malignant tumor cells in an osteosarcoma