What are mediators of immune injury in kidneys?

➢ A major pathway of antibody-initiated glomerular injury involves complement activation and recruitment ➢Activation of complement via the classical pathway leads to the generation of chemotactic agents (mainly C5a) for neutrophils and monocytes. ➢ Neutrophils release proteases, which cause GBM degradation; ➢ Oxygen-derived free radicals, which cause cell damage; ➢ Arachidonic acid metabolites, which contribute to reduction in GFR. ➢In addition to neutrophils and monocytes, which are recruited by antibodies and complement, T lymphocytes activated during the immune reaction also have been implicated in glomerular injury