What are clinical features of membraneous nephropathy?

➢ Most cases of membranous nephropathy are sudden in onset and present as fullblown nephrotic syndrome, usually without antecedent illness; ➢ other individuals have lesser degrees of proteinuria. ➢ In contrast to minimal-change disease, the proteinuria is nonselective, and usually fails to respond to corticosteroid therapy. ➢ Secondary causes of membranous nephropathy should be ruled out. ➢ Membranous nephropathy follows a notoriously variable and often indolent course. ➢ Overall, although proteinuria persists in greater than 60% of patients, only about 40% progress to renal failure over a period of 2 to 20 years. ➢ An additional 10% to 30% of cases have a more benign course with partial or complete remission of proteinuria