What is membranoproliferative glomerulonephritis?

➢ MPGN is manifested histologically by alterations in the GBM and mesangium and by proliferation of glomerular cells. ➢ It accounts for 5% to 10% of cases of idiopathic nephrotic syndrome in children and adults. ➢ Some patients present only with hematuria or proteinuria in the nonnephrotic range; others exhibit a combined nephroticnephritic picture. ➢ In the past, MPGN was subclassified into two types (I and II) on the basis of distinct ultrastructural, immunofluorescence, light microscopic, and pathogenic findings. ➢ These are now recognized to be distinct entities, termed MPGN type I and dense deposit disease (formerly MPGN type II). ➢ MPGN type I is far more common (about 80% of cases). ➢ Dense deposit disease is a related condition of C3 glomerulonephritis.