How is pathogenesis of post infectious glomerulonephritis?

➢Poststreptococcal GN is an immune complex disease in which tissue injury is primarily caused by complement activation by the classical pathway. ➢Typical features of immune complex disease, such as hypocomplementemia and granular deposits of IgG and complement on the GBM are seen. ➢The relevant antigens probably are streptococcal proteins. ➢Specific antigens implicated in pathogenesis include streptococcal exotoxin B (Spe B) and streptococcal glyceraldehyde-3-phosphate dehydrogenase (GAPDH). ➢Both have an affinity for glomerular proteins and plasmin. ➢It is not clear if immune complexes are formed mainly in the circulation or in situ (the latter by binding of antibodies to bacterial antigens “planted” in the GBM)