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Clinical Immunology

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Question:

What are types of autoimmunity? Acc to cell type

Author: H K



Answer:

T cell (Like MS or AI encephalomyelitis, strength of T cell reactivation deteremines degree of parenchymal inflammation) B cell (autoantibodies, Like SLE, can be transmitted transplacentally [neonatal Grave's, congentital herat block, neonatal lupus], IgG antibodies cross placenta while IgM don't. half life of IgG 21-28 days so go to baby circulation in 6-12 months postpartum, mostly transient [exception is complete heart block mediated by anti-Ro/anti-La autoantibodies cross reacting w/cardiac antigens causing permenant inflammation and damage]. Usually several mechanisms [T cell and antibody tissue injury]


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H K
H K