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Clinical Immunology

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Question:

How is infectious vasculitis?

Author: H K



Answer:

➢ When an adaptive antibody response fails to clear an infectious agent, for example in subacute bacterial endocarditis or chronic viral hepatitis. ➢ In this situation, the multiplying bacteria or viruses are continuously generating new antigen in the presence of a persistent antibody response that fails to eliminate the organism. ➢ ICs disease ensues, with injury to small blood vessels in many tissues and organs, including the skin, kidneys, and nervesOther causes of infectious vasculitis; Post streptococcal glomerulonephritis (in fighting a strep infection, the patient makes an antibody that reacts against the strep but also cross-reacts with some antigen in the glomerulus; ICs lodge there and cause nephritis), Hepatitis, Meningitis, Mononucleosis, Malaria, Lyme arthritis, Trypanosomiasis,…


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H K
H K