What is active cancer immunotherapy?

Intended to inhibit immunosuppressive mechanisms and amplify antigen-specific T cell responses Three approaches used : — Checkpoint inhibitors: mAbs antagonists of inhibitory signals — CAR-T cell therapy: Patient treatment with modified autologous T cells — Therapeutic cancer vaccines: Tumor antigens or genes encoding for these Ags, that either activate pre-existing host antitumor immune cells or induce the differentiation of new ones