How is CAR-T cell therapy for cancer?

Autologous live reprogrammed T cell therapy Patients are treated with their own T cells transfected with CAR CAR: Chimeric Antigen Receptor. Generations 1 to 3 consist of: — A tumor antigen-binding domain (scFv fragment of a tumor-specific Ab: VH+VL) + a trans-membrane region anchoring scFv to the cell — One or more intra-cellular signaling domains containing ITAM, that activate the T cell upon Ag binding