Question:
What are the two FDA approved CAR-T cell therapy?
Author: H KAnswer:
Tisagenlecleucel: CD19-targeted T cells. Trade Name: Kymriah Approved in August 2017 for the treatment of acute lymphocytic leukemia (ALL) of pro-B cells in pediatric and young adult patients Survival rate after 3 months : 83% in relapsed ALL patients Axicabtagene: CD19-targeted T cells. Trade name: Yescarta Approved by the FDA in October 2017 for the treatment of Diffuse Large B cell Lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma Indicated in adults who failed 2 previous therapies Side effects: cytokine release syndrome and neurologic events, potential fatal
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H K