Principles of pharmacology: factors overall affecting drug distribution and metabolism - PATIENT AND DRUG

Question

factors overall affecting drug distribution and metabolism - PATIENT AND DRUG

Gen Bailey · Accepted Answer

Patient Factors:
Age (neonates and elderly have reduced metabolism).
Genetic polymorphisms (e.g., variations in CYP enzymes).
Liver and kidney function.
Drug Interactions:
Enzyme inducers (e.g., rifampin) increase metabolism.
Enzyme inhibitors (e.g., ketoconazole) decrease metabolism.

Principles of pharmacology

Factors overall affecting drug distribution and metabolism - PATIENT AND DRUG

Patient Factors: Age (neonates and elderly have reduced metabolism). Genetic polymorphisms (e.g., variations in CYP enzymes). Liver and kidney function. Drug Interactions: Enzyme inducers (e.g., rifampin) increase metabolism. Enzyme inhibitors (e.g., ketoconazole) decrease metabolism.

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