Rifampin toxicity

Rifampin commonly causes light-chain proteinuria and may impair antibody responses. skin rashes, thrombocytopenia,nephritis, and liver dysfunction nausea vomiting hepatitis and liver failure rare but shouldnt be used for elderly and alcoholics increased incidence with isoniazid If given less than twice weekly, rifampin may cause a flu-like syndrome and anemia, fever, chills, and myalgias, acute renal failure, hemolytic anemia, and shock. Rifampin strongly induces liver drug-metabolizing enzymes and enhances the elimination rate of many drugs, including anticonvulsants, contraceptive steroids, cyclosporine, ketoconazole, methadone, terbinafine, and warfarin.