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pharmacology chemotherapy

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Question:

Resistance hiv protease inhibitors

Author: Suzuki



Answer:

Resistance occurs as an accumulation of stepwise mutations of the protease gene. Initial mutations result in decreased ability of the virus to replicate, but as the mutations accumulate, virions with high levels of resistance to the protease emerges. Suboptimal concentrations result in the more rapid appearance of resistant strains.


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Suzuki
Suzuki