Fluconazole

Fluconazole  is a member of the triazole class of antifungal products. its lack of the endocrine side effects of ketoconazole and its excellent penetrability into the CSF of both normal and inflamed meninges. Fluconazole is administered orally or intravenously. Its absorption is excellent and, unlike that of ketoconazole, is not dependent on gastric acidity. Binding to plasma proteins is minimal.Unlike ketoconazole, fluconazole is poorly metabolized. The drug is excreted via the kidney, and doses must be reduced in patients with compromised renal function. The adverse effects caused by fluconazole treatment are less of a problem than those with ketoconazole. Fluconazole has no endocrinologic effects because it does not inhibit the CYP450 system responsible for the synthesis of androgens. However, it can inhibit the P450 cytochromes that metabolize other drugs listed Nausea, vomiting, and rashes are a problem. There is a caution for patients with liver dysfunction. Fluconazole is teratogenic, as are other azoles, and should not be used in pregnancy.