Disulfiram

Disulfiram: Disulfiram blocks the oxidation of acetaldehyde to acetic acid by inhibiting aldehyde dehydrogenase. This results in the accumulation of acetaldehyde in the blood, causing flushing, tachycardia, hyperventilation, and nausea. Disulfiram has found some use in the patient seriously desiring to stop alcohol ingestion. A conditioned avoidance response is induced so that the patient abstains from alcohol to prevent the unpleasant effects of disulfiram-induced acetaldehyde accumulation.