Mefloquine pharmacokinetics and adverse effects

Absorbed well after oral administration and concentrates in the liver and lung. It has a long half-life (17 days) because of its concentration in various tissues and its continuous circulation through the enterohepatic and enterogastric systems. The drug undergoes extensive metabolism. Its major excretory route is through the feces. Adverse reactions at high doses range from nausea, vomiting, and dizziness to disorientation, hallucinations, and depression. ECG abnormalities and cardiac arrest are possible if mefloquine is taken concurrently with quinine or quinidine.