Cyclophosphamide moa

Hepatic cytochrome P450-mediated biotransformation of cyclophosphamide is needed for antitumor activity. One of the breakdown products is acrolein.Unlike most of the alkylating agents, cyclophosphamide and ifosfamide can be administered by the oral route After oral administration, minimal amounts of the parent drug are excreted into the feces (after biliary transport) or into the urine by glomerular filtration.