Nitrosoureas pharma

In spite of the similarities in their structures, carmustine is administered IV, whereas lomustine is given orally. Because of their lipophilicity , they distribute widely in the body to many tissues, but their most striking property is their ability to readily penetrate the CNS. The drugs undergo extensive metabolism. Lomustine is metabolized to active products. The kidney is the major excretory route for the nitrosoureas