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pharmacology chemotherapy

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Question:

Pharmacologic sanctuaries:

Author: Suzuki



Answer:

Leukemic or other tumor cells find sanctuary in tissues such as the central nervous system (CNS), where transport constraints prevent certain chemotherapeutic agents from entering. Therefore, a patient may require irradiation of the craniospinal axis or intrathecal administration of drugs to eliminate the leukemic cells at that site. Similarly, drugs may be unable to penetrate certain areas of solid tumors.


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Suzuki
Suzuki