Dementia of alzheimer

Only palliative and provides modest short-term benefit. None of the currently available therapeutic agents have been shown to alter the underlying neurodegenerative process. Dementia of the Alzheimer typea has three distinguishing features: 1) accumulation of senile plaques (β-myloid accumulations); 2) formation of numerous neurofi brillary tangles; and 3) loss of cortical neurons, particularly cholinergic neurons. Current therapies are aimed at either improving cholinergic transmission within the CNS or preventing excitotoxic actions resulting from overstimulation of NMDA-glutamate receptors in selected brain areas.