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Chapter 15 - Gene Regulation


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[Front]


Regulation can occur at any step in the expression process, but most often it is done at
[Back]


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Highly acetylated-
Heterochromatin
Highly condensed-
Heterochromatin
Gene poor-
Heterochromatin
Gene rich-
Euchromatin
MiRNAs cause-
To be degraded
The TATA box is part of-
The core promoter
RNA polymerase binds to-
The core promoter
Phosphorylation is a form of-
Post-translarional modification
A single gene can code for
For more than one type of protein
Eukaryotic Initiation Factor 2 (e-IF-2) must be
Dephosphorylated before translation can occur.
The proteasome-
Destroys proteins
Methylation of DNA and histones causes nucleosomes to
Pack tightly together with no transcription and express
Histone acetylation results in
Loose packing of nucleosomes with trtranscrption and express
Epigenetic changes to the chromatin may result from
Aging Diet, drug, development and environmental chemical
Epigenetic changes may result in
Cancer, Autoimmune disease, mental disorders and diabetes.)
Histones are proteins around which
DNA winds for compaction and gene regulation
Dna methylation and chemical modification of histone tails alter
The spacing of nucleosomes and change gene expression.
The major steps of transcription are
Initiation, promoter clearance, elongation, and termination.
The longer a protein “lives”,
The more proteins can be translated from it
MiRNAs cause-
To be degraded
Dicer –
Protein that cuts double-stranded RNA
RISC – RNA-
Induced Silencing Complex
When elf-2 is phosphorylates,
Translation is blocked