Chapter 15 - Gene Regulation
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Chapter 15 - Gene Regulation - Leaderboard
Chapter 15 - Gene Regulation - Details
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Regulation can occur at any step in the expression process, but most often it is done at | Transcription |
Found in chromosome arms - | Euchromatin |
Found in centromeres and telomeres- | Heterochromatin |
Highly acetylated- | Heterochromatin |
Highly condensed- | Heterochromatin |
Gene poor- | Heterochromatin |
Gene rich- | Euchromatin |
MiRNAs cause- | To be degraded |
The TATA box is part of- | The core promoter |
Repressors bind to - | Silencers |
RNA polymerase binds to- | The core promoter |
Phosphorylation is a form of- | Post-translarional modification |
A single gene can code for | For more than one type of protein |
Eukaryotic Initiation Factor 2 (e-IF-2) must be | Dephosphorylated before translation can occur. |
The proteasome- | Destroys proteins |
Methylation of DNA and histones causes nucleosomes to | Pack tightly together with no transcription and express |
Histone acetylation results in | Loose packing of nucleosomes with trtranscrption and express |
Epigenetic changes to the chromatin may result from | Aging Diet, drug, development and environmental chemical |
Epigenetic changes may result in | Cancer, Autoimmune disease, mental disorders and diabetes.) |
Histones are proteins around which | DNA winds for compaction and gene regulation |
Dna methylation and chemical modification of histone tails alter | The spacing of nucleosomes and change gene expression. |
The major steps of transcription are | Initiation, promoter clearance, elongation, and termination. |
Proteins that help (activators) bind to | Enhancer sequences |
Proteins that hinder (repressors) bind to | Silencer sequences |
The longer a protein “lives”, | The more proteins can be translated from it |
MiRNAs cause- | To be degraded |
Dicer – | Protein that cuts double-stranded RNA |
RISC – RNA- | Induced Silencing Complex |
When elf-2 is not phosphorylates, | Translation occurs |
When elf-2 is phosphorylates, | Translation is blocked |
Transcription initiation | 1,2.3.4 |
Ubiquitin – 76 amino acid protein found in | All eukaryotes |
RBPs bind to the untranslated regions and determine the | “lifespan” of a particular mRNA |