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PHARMCARE 3


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[Front]


the use of traditional compounding techniques to manipulate chemical ingredients to produce appropriate dosage forms when no commercial medicine form is available
[Back]


Extemporaneous compounding

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PHARMCARE 3 - Details

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Quality control FOR 1 Oral and topical liquids 2 Hard gelatin capsules
. 1 pH, sp. Gravity, assays, rheological properties, physical observation, physical stability 2 weight variation, dissolution and disintegration
Quality control FOR 1 Ointments, creams and Gels 2 Suppositories, Trouches
. 1 pH, sp. Gravity, assay, rheological properties 2 melting points, dissolution test, physical stability
Quality control FOR 1 Parenteral Preparation
. 1 pH, sp. Gravity, osmolality, color, clarity, particulate matter, sterility
Risks associated with extemporaneous compounding:
1 Formulation Failure 2 Microbial contamination 3 Calculation errors 4 Starting materials 5 Patient Accessibility issues 6 Health and Safety Risk 7 Therapeutic risks and clinical consequences
Principles of Medication Review
1. All patients should have a CHANCE TO RAISE QUESTIONS and highlight problems about their medicines. 2. Medication review SEEKS TO IMPROVE OR OPTIMIZE impact of TREATMENT for a patient 3. The review is undertaken in a SYSTEMATIC WAY, by a competent person 4. Any CHANGES resulting from the review are AGREED WITH THE PATIENT 5. The review is DOCUMENTED in the patient’s notes 6. The impact of any change is MONITORED
Type of Medication review
Type 1: Prescription Review Type 2: Concordance and Compliance Review Type 3: Clinical Medication Review PCC
Review Process
1. Identify patients 2. Carry out the review 3. Record review outcomes / Feedback results 4. Audit / Quality assurance ICRA
(Carrying out the review) Ten-point medication review
1 Why is this patient taking this drug? 2 Is the reason clear from the history summary? 3 Is the patient capable of taking this drug and is compliance satisfactory? 4 Are any tests required to monitor side-effects or dosage? 5 Are there any potential drug interactions and are they of significance? 6 What would happen if the drug was stopped? 7) Does the repeat need to be continued for the next 6 or 12 months? 8)Are any non-repeat items being prescribed regularly? 9 Should these be converted to formal repeats? 10 Set a date for the next review?
Recording the review outcomes
Level 1: REVIEW OF A LIST OF THE MEDICATION under the direction of doctor, nurse or pharmacist, but in the ABSENCE OF THE PATIENT Level 2: TREATMENT REVIEW UNDER THE direction of a doctor, nurse or pharmacist, in the ABSENCE OF THE PATIENT but with REFERENCE to the CODING ONLY PATIENT’S CLINICAL RECORD Level 3: CLINICAL MEDICATION REVIEW specifically undertaken by a doctor, nurse or pharmacist in the PRESENCE OF THE PATIENT with ACCESS to the PATIENT’S CLINICAL RECORD and LABORATORY TEST RESULTS as required
Who does the Review?
In practice doctors, pharmacists and many nurses have the clinical skills and therapeutic knowledge to perform all aspects of medication review
(What should the review cover? ) For each drug: Check that:
1 The medication prescribed is APPROPRIATE for the patient’s needs 2 The medication is EFFECTIVE for the patient 3 The medication is a COST EFFECTIVE choice 4 Any required MONITORING has been done or arrangements are in place
The NO TEARS Mnemonic to Aid Medication Review in a 10 Minute Consultation 10
N Need and Indication O Open Questions T Tests and Monitoring E Evidence and Guidelines A Adverse Events R Risk reduction or prevention S Simplification and switches
Type 3: Clinical Medication Review When to do it?
Patient’s with long-term conditions Patient with recently diagnose long-term conditions Patient experienced an adverse event associated with medicine-taking Patient/Carer requests a review or reports they have stopped taking prescribed medicine.
Type 1: Prescription Review When to do it?
1 Patient’s with long-term conditions 2 Patient with recently diagnose long-term conditions 3 Patient experienced an adverse event associated with medicine-taking 4 Patient/Carer requests a review or reports they have stopped taking prescribed medicine.
Type 1: Prescription Review When to do it?
1 Patient is IN THE HOSPITAL or TRANSFERRED BETWEEN CARE SETTINGS 2 REVIEWING PRACTICE for a class of medicine
Type 2: Concordance and Compliance Review When to do it?
1 PATIENT IS DISCHARGED from the hospital 2 Patient has NEW MEDICINE 3 Patients with LONG TERM CONDITIONS WITH MULTIPLE MEDICATIONS 4 Clinician IDENTIFIED a MEDICATION RELATED PROBLEM
Type 3: Clinical Medication Review When to do it?
1 Patient’s with LONG-TERM CONDITIONS 2 Patient with RECENTLY DIAGNOSE LONG-TERM CONDITIONS 3 Patient experienced an ADVERSE EVENT ASSOCIATED WITH MEDICINE-TAKING 4 Patient/Carer REQUESTS A REVIEW OR REPORTS they have STOPPED TAKING PRESCRIBED MEDICINE.
Types of Non-adherence
1 Non-fulfillment 2 Non-persistence 3 Non-conforming
Non-fulfillment give examples
1 Prescription is never filled
Non-persistence give examples
- Px stopped taking the medication after taking it rarely intentional (due to miscommunication, reduced capacity, etc)
Non-conforming give examples
1 Medication is not taken as prescribed 2 Missed doses, Incorrect doses, Dose taken at the wrong time
Adherence is a multidimensional phenomenon determined by the interplay of FIVE SETS OF FACTORS, termed "DIMENSIONS" by the World Health Organization: In simple terms: GIVE FIVE SET OF FACTORS OF ADHERENCE
1. Social/economic factors 2. Provider-patient/health care system factors 3. Condition-related factors 4. Therapy-related factors 5. Patient-related factors SP CTP
1. SOCIAL AND ECONOMIC DIMENSION give examples
1 limited english proficiency 2 low health literacy 3 lack of family and social support network 4 unstable living conditions 5 burdensome schedule 6 limited access to healthcare facilities 7 lack of health care insurance 8 inability/difficulty accessing pharmacy 9 medication cost 10 cultural and lay beliefs 11 elder abuse
THERE ARE SEVERAL WAYS TO MEASURE MEDICATION ADHERENCE.
1. Medication Event Monitoring Systems (MEMS) - the most accurate 2. Patient self-reports - easiest method 3 Pill Counts 4 Pharmacy databases or Refill rates 5 Blood levels 6 Morisky's Medication Adherence Scale (MMAS) 2M3PB
HEALTH CARE SYSTEM DIMENSION give examples
1 provider-patient relationship 2 provider communication skills 3 disparity between the health beliefs of the health care provider and those of the patient 4 lack of positive reinforcement from healthcare provider 5 weak capacity of the system to educate px and follow up 6 lack of knowledge on adherence and of effective interventions for improving it 7 px information materials written at high literacy level 8 restricted formularies; changing meds covered on formularies 9 high drug cost 10 poor access or missed appointments 11 long wait times 12 lack of continuity of care
These are the MOST ACCURATE method of measuring adherence because they record the date and time the medication bottle was OPENED THROUGH MICROPROCESSOR technology embedded in the cap. (GIVE THE disadvantages of this)
Medication Event Monitoring Systems (MEMS) Disadvantages: 1 erroneous/not faith/falls., because pt may remove more than one dose 2 Very expensive & different devices are needed for each medication 3 Therefore it is an impractical way to determine adherence in clinical practice.
CONDITION-RELATED DIMENSION give examples
1 chronic 2 lack of symptoms 3 severity of symptoms 4 depression 5 psychotic disorders 6 mental retardation/ developmental disability
Methods that can improve Medication Adherence by Pharmacists iisa ang method
1 Improve PHARMACY WORKFLOW 2 SIMPLIFY Patient’s Medications 3 IDENTIFY REASONS for Medication Non-adherence 4 ASK PATIENTS SPECIFIC QUESTIONS about their Medication IISA
ROLE of Pharmacists in ADHERENCE
1 PX education 2 Dosing simplification & minimization of A/E 3 Preparing a dosing card PDP
1. SOCIAL AND ECONOMIC DIMENSION give examples
1 LIMITED ENGLISH PROFICIENCY 2 LOW HEALTH LITERACY 3 LACK OF FAMILY AND SOCIAL SUPPORT NETWORK 4 UNSTABLE LIVING CONDITIONS 5 burdensome schedule 6 LIMITED ACCESS to healthcare facilities 7 lack of health care insurance 8 inability/DIFFICULTY ACCESSING PHARMACY 9 MEDICATION COST 10 cultural and lay beliefs 11 elder abuse
HEALTH CARE SYSTEM DIMENSION give examples
1 PROVIDER-PATIENT RELATIONSHIP 2 PROVIDER COMMUNICATION SKILLS 3 disparity between the health beliefs of the health care provider and those of the patient 4 LACK OF POSITIVE REINFORCEMENT from healthcare provider 5 WEAK CAPACITY of the system TO EDUCATE PX AND FOLLOW UP 6 LACK OF KNOWLEDGE ON ADHERENCE and of effective interventions for improving it 7 px information materials written at HIGH LITERACY LEVEL 8 restricted formularies; changing meds covered on formularies 9 HIGH DRUG COST 10 POOR ACCESS OR MISSED APPOINTMENTS 11 LONG WAIT TIMES 12 LACK OF CONTINUITY OF CARE
CONDITION-RELATED DIMENSION give examples
1 chronic 2 lack of symptoms 3 severity of symptoms 4 depression 5 psychotic disorders 6 mental retardation/ developmental disability
THERAPY-RELATED DIMENSION give examples
1 COMPLEX MEDICATION REGIMEN 2 TREATMENT REQUIRES MASTERY of certain techniques 3 DURATION OF THERAPY 4 FREQUENT CHANGES IN MED REGIMEN 5 LACK OF IMMEDIATE BENEFIT OF THERAPY 6 medications with SOCIAL STIGMA attached use 7 ACTUAL OR PERCEIVED UNPLEASANT SIDE EFFECTS 8 TREATMENT INTERFERES WITH LIFESTYLE or requires significant behavioral changes
PATIENT-RELATED DIMENSION give examples
PHYSICAL FACTORS - visual, hearing, cognitive, mobility impairment - swallowing problems PSYCHOLOGICAL/BEHAVIORAL FACTORS - knowledge about dx - perceived risk - understanding reason meds is needed - attitude toward treatment - confidence in ability to follow treatment regimen - motivation - fear of possible a/e - fear of dependence - feeling stigmatized by the dx - frustration w/ health care providers - stress, anxiety - alcohol or susbtance use
Why is Pharmaceutical Care Important?
1 MULTIPLE PRESCRIBERS 2 EXPLOSION DRUG PRODUCTS AND DRUG INFORMATION 3 Increase COMPLEXITY OF DRUG THERAPY 4 Significant level of DRUG-RELATED MORBIDITY AND MORTALITY 5 HIGH FINANCIAL COST of drug misadventure 6 Social NEED TO ADDRESS DRUG-RELATED PROBLEMS (DRP) MEI SHS
Primary Responsibilities of Pharmacist
A. To ensure patient’s drug therapy is safe, effective and efficient b. To identify, resolve, and prevent any DRPs c. To ensure that the patient’s therapeutic goals are met and optimal health-related outcomes are attained
Drug Therapy 1 Objectives 2 Outcome
. 1 > Cure > Reduce or eliminate symptom > Slow down disease progression > Prevention 2 > ↑ pt. quality of life/wellbeing > ↑ work productivity > Save cost
Pharmaceutical Care Process
1 Collect 2 Assess 3 Plan 4 Implement 5 Monitor 6 Follow Up CAPtain IMF
Constructing PCP
1. IDENTIFY THE PHARMACEUTICAL CARE ISSUES >”medical-related problems” ex. Uncontrolled BP, irregular home glucose monitoring, non-compliance to diet 2. PRIORITIZE the care issues 3.Determine the ACTION to be taken 4. RECORD the action taken 5. Record the OUTCOME of the action taken IP DRR
Various ways to document patient care & PCP
A. SOAP format b. FARM format c. “IAO” (care issues, action, outcome) format
Challenges in Pharmaceutical Care
1. Knowledge and skills update 2. Communication with patient 3. Communication with doctors 4. Time management KCC Ta
“IAO” Format
>I= care issues similar to A in the SOAP > A= action (“pharm care action”) similar to P in the SOAP > O= outcome To document the outcome of the action carried out
TYPES OF MEDICATION RELATED PROBLEMS
1 Meds requires NEW or ADDITIONAL DRUG THERAPY that is NOT PRESCRIBED 2 Patient is taking UNNECESSARY DRUG 3 WRONG DRUG for patients condition or age 4 patient NOT TAKING DRUG CORRECTLY 5 CORRECT DRUG, DOSE TOO LOW 6 CORRECT DRUG, DOSE TOO HIGH 7 ADVERSE DRUG REACTION / DRUG INTERACTION
How to Prevent? MRPs
1 Communicate effectively with health care providers about medications. 2 Designate a medication manager. 3 Keep a medication list. 4 Consult with a doctor or pharmacist before taking over-the-counter medication, alcohol or herbal supplements along with prescription drugs. 5 Use common sense when using medications. 6 Obtain medication refills in a timely manner.