Question:
How does telomerase work?
Author: Shay 1vccAnswer:
Telomerase uses the 3′–OH of the G+T telomeric strand to prime synthesis of tandem TTGGGG repeats. The RNA component of telomerase has a sequence that pairs with the C+A-rich repeats. One of the protein subunits is a reverse transcriptase that uses the RNA as template to synthesis the G+T-rich sequence. -Telomerase positions itself by base pairing between the RNA template and the protruding single-stranded DNA primer.
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![Telomerase uses the 3′–OH of the G+T telomeric strand to prime synthesis of tandem TTGGGG repeats.
The RNA component of telomerase has a sequence that pairs with the C+A-rich repeats.
One of the protein subunits is a reverse transcriptase that uses the RNA as template to synthesis the G+T-rich sequence.
-Telomerase positions itself by base pairing between the RNA template and the protruding single-stranded DNA primer.](https://markdown.memory.com/eq_uploads/1085614/9367ca7e-5a8d-40ef-bd79-915f301a6b65.jpg)
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Shay 1vcc![Shay 1vcc](https://markdown.memory.com/eq_uploads/1085614/c84eba53-845c-4d66-9db7-78e83b3c066f.jpg)