What is Allelic exclusion relation the b-cell selection?

Pre-BCR complex also send signal to inhibit recombination on the homologous chromosome, so only one allele will express BCR of single specificity. -If k light chain fail to produce functional receptor or k light chain encodes a self-reacting BCR, then BCR will trigger recombination of k with ⋋ light chain. If functional IgM receptor is produced it will send survival signal, otherwise – apoptosis. Signals from IgM will also shut off light chain recombination, so either k or ⋋ light chains are made by given B cells.