Question:
What is the role guide RNAs in RNA editing?
Author: Shay 1vccAnswer:
The substrate RNA base pairs with a guide RNA on both sides of the region to be edited. The guide RNA provides the template for addition (or less often, deletion) of uridines. Editing is catalyzed by the editosome, a complex of endonuclease, exonuclease, terminal uridyl transferase activity, and RNA ligase.
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