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BBS2001 Threats and Defence Mechanisms
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Question:
What drugs/structures can be used to treat arterial thrombosis?
Author: Mirte SchattorieAnswer:
Aspirin: inhibits cyclooxygenase, prevents autofeedback mechanism that amplifies platelet activation ADP-receptor antagonist (clopidogrel): inhibits ADP receptor, ADP cannot bind, less platelets will be attracted. PAR1 inhibition: thrombin cannot bind to its receptor, cannot amplify the cascade. receptor integrin alpha 2b beta 3 inhibition: reduces platelet aggregation by inhibiting binding of platelets to fibrinogen
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