 This is the MOST EXTENSIVELY DISTRIBUTED OF ALL 5-HT RECEPTORS. In CNS, these receptors are present in high density in cerebral cortex, hippocampus, septum, amygdala, but they are proven in small amounts in basal ganglia and thalamus as well.  They are involved in the INHIBITION OF DISCHARGE OF NEURONS, regulation of production of behavior and eating.  They play an important role in the EMERGENCE OF ANXIETY.  They also exert some effects on CV system.