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Endocrinology

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Question:

What are the tests done for dx of primary hyperaldosteronism?

Author: H K



Answer:

Plasma potassium (not constant) 24-hour urinary potassium (increased excretion >30 with high salt diet ) Screening test (morning stimulation of aldosterone and renin and see PA/PRA ratio done twice (PA/PRA >30 strongly primary hyperaldo with 90% spec and sens, >70 is diagnostic) Confirmation required if PA/PRA btw 30-70, either measure PA after suppression with IV saline or fludrocortisone , if aldo >10 --> primary hyperaldo Or Urine aldo after high salt diet, if >14 confirmed Be cautious of giving salt IV with heart issues


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H K
H K