Question:
What are the characteristics in favor of adenoma over bilateral hyperplasia?
Author: H KAnswer:
Young age (<50 years) Severe hypokalaemia (<3.0 meq / L) Very high aldosterone levels: Aldosterone plasma> 25ng / dl, urinary aldosterone > 30μg / 24hr Absence of elevation of plasma aldosterone to the orthostatism test Bilateral hyperplasia appears to be due to hypersensitivity to angiotensin II therefore when going to orthostatism, angio II increases or aldosterone increases. This is not observed in the adenoma. . 18-OH-B (18-OH-corticosterone)> 100ng / dl
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