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Pharmacology

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Question:

What are the CYPs found in humans?

Author: H K



Answer:

12 CYPs (CYP1A1,1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4, and 3A5) are the ones involved in oxidation of xenobiotics, seen in the liver, some in GI, lungs, kidneys, and CNS. Most active ones are CYP2C, 2D and 3A CYP3A4 is most abundant and used in metabolism of 50% of used drugs. other subfamilies are not involved in drug metabolism but in activation of protoxins and procarcinogens (CYP1A, CYP1B, CYP2A, CYP2B, and CYP2E ).


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H K
H K