Question:
Give examples on receptor down and up-regulation?
Author: H KAnswer:
Downregulation in case of prolonged agonists (chronic use of salbutamol (adrenergic agonist) down regulated beta-receptors- decreased effect of salbutamol in asthmatic pt)) Upregulation in case of prolonged antagonist effect (withdrawal of beta blockers (propranolol) suddenly, causes withdrawal symptoms anxiety palpitation tachycardia, htn,
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H K![H K](https://lh4.googleusercontent.com/-V3rEIOcuFis/AAAAAAAAAAI/AAAAAAAAAAA/AMZuucnhTzvoiq2vqvBJhe7t9kqRkO_jNw/s96-c/photo.jpg)