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Endocrinology

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Question:

What is secondary adrenal insufficiency?

Author: H K


Answer:

ACTH deficiency Acquired (iatrogenic - sudden cessation of exogenous cortisol/ treated Cushing's after adenoma removal/ hypopituitarism/ isolated ACTH deficiency) Inherited causes (isolated defect in TPIT mutation (promoter of POMC)/ post-translational defect processing POMC to ACTH by prohormone convertase 1 or 2 (PC1/2 mutation)/ POMC gene mutation (red hair pigmentation due to decreased MSH)


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ACTH deficiency Acquired (iatrogenic - sudden cessation of exogenous cortisol/ treated Cushing's after adenoma removal/ hypopituitarism/ isolated ACTH deficiency) Inherited causes (isolated defect in TPIT mutation (promoter of POMC)/ post-translational defect processing POMC to ACTH by prohormone convertase 1 or 2 (PC1/2 mutation)/ POMC gene mutation (red hair pigmentation due to decreased MSH)
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Author

H K
H K