How is pathogenesis of HF?

Baroreceptor dysfunction, decreased afferent inhibitory signals, increased sympathetic NS and decreased limb blood flow with increased vasopressin secretion, renin secretion, aldosterone, sodium reabsorption and water retention This causes HFrEF caused by increased BP, hypertrophy,fibrosis (by RAAS), HR, vasopressin, contractility (SNS).