TOXICITY NOT INITIATED BY REACTION WITH TARGET MOLECULES 1 Some xenobiotics ALTER THE BIOLOGICAL MICROENVIRONMENT leading to a toxic response. Included here are:

1) Chemicals that ALTER H+ CONCENTRATIONS in the aqueous biophase 2 Solvents and detergents that physicochemically ALTER THE LIPID PHASE of cell membranes and destroy transmembrane solute gradients, 3 Xenobiotics that cause harm merely by OCCUPYING A SITE.