What is ischemia?

Decrease in arterial blood supply in a limited area of body, causes hypoxia/anoxia. causes include partial or total obliteration of arterial lumen (atherosclerosis, arteritis, thrombosis, embolism, compression, prolonged arterial spasm, arterial dissection) Factors influencing impact (intesity, duration, sensitivity of tissues (neurons, myocardium epithelia very sensitive), possibility of substitue circulation like anastomse/collaterals, rapid installation (sudden no time for replacement, prolonged irreversible cell damage)