How is synthesis of atherosclerosis?

➢Damage to the endothelium leads to increased patency and adhesion of platelets. ➢Lipoproteins enter the intima. ➢These lipoproteins undergo oxidative degradation. ➢Monocytes adhere to the intima, penetrate it, are activated, phagocytose the released lipids and transform into foamy macrophages. ➢Growth factors are produced. They lead to the migration of muscle cells from the media to the intima, their multiplication, the elaboration of an extracellular collagen matrix on which mineral salts (in particular calcium) are deposited. ➢Complications occur, especially as soon as the intima is ulcerated (thrombosis and embolisms) and the elastic laminae are destroyed (aneurysm).