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Rheumatology

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Question:

What are extrapulmonary manifestations of sarcoidosis (Opthalmic, neurological and others)?

Author: H K



Answer:

Ophthalmic (anterior uveitis, posterior uveitis, retinal vasculitis, keratoconjuctivitis, scleritis (very rare), conjuctival follicles) Neurological (5% of pt, females mainly, early in disease, life threat, agranulomatous meningitis with infiltrates and compression, cognitive or psychic manifestations (most common, seizures, headache, hypothalamic, hypopituotarism, DI, hydrocephalus, facial palsy) periphearl neuropathy, correlated with cardiac invovlement) Reticuloendothelial, GI, Reproductive, endocrine and exocrine glands [parotid in Heerfordt's syndrome, r/o sjogren], renal and electrolyte [Ca metabolism abnormality due to hyperproduction of Vit D extrarenal], Cardiac disease [most serious, infiltrate of ventricular septum, cause arrhythmias, heart block, sudden death, palpitations, syncope, dizziness, chest pain, see cardiac PET/MRI)


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H K
H K