How is atherosclerosis initiation?

Extracellular lipid accumulation, then leukocyte recruitment and retention, then focality of lesion formation, then intracellular lipid accumulation (foam cell formation) Evolution (innate and adaptive immunity, smooth muscle cell migration and proliferation, then smooth muscle cell death during atherogenesis, then arterial ECM, angiogenesis in plaques and finally plaque mineralization. Clinical complications of atherosclerosis traditionally used to be exponential, nowadays it became random and faster)