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Pharmacology

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Question:

What is mechanism of action of Ezetimibe?

Author: H K



Answer:

Ezetimibe selectively inhibits intestinal absorption of dietary and biliary cholesterol in the small intestine, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood. It lowers LDL cholesterol by 17 % and TG by 6%, It increases HDL cholesterol by 1.3 % Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation (a Phase II reaction), with subsequent biliary and renal excretion


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Author

H K
H K