Question:
What is mechanism of action of Ezetimibe?
Author: H KAnswer:
Ezetimibe selectively inhibits intestinal absorption of dietary and biliary cholesterol in the small intestine, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood. It lowers LDL cholesterol by 17 % and TG by 6%, It increases HDL cholesterol by 1.3 % Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation (a Phase II reaction), with subsequent biliary and renal excretion
0 / 5 Â (0 ratings)
1 answer(s) in total