How is tx by statins in combination with other antihyperlipidemic?

It is often necessary to use two antihyperlipidemic drugs to achieve treatment goals in plasma lipid levels. 1. The combination of an HMG CoA reductase inhibitor (lovastatin) with a bile acid–binding agent (colestipol) has been shown to be very useful in lowering LDL-C levels 2. simvastatin and niacin as well as simvastatin and ezetimibe, are currently available combined in one pill to treat elevated LDL cholesterol. 3. A fixed combination of simvastatin and ezetimibe decreases LDL-C levels by up to 60% at 24 weeks