How is presentation of rhabdomyosarcoma?

• Bulky, invasive, central necrosis • Almost always myocardial involvement • May involve mitral valve or atrial wall • Malignant soft tissue tumors, exhibiting skeletal muscle differentiation. • Tumor cells range from small primitive hyperchromatic round/spindle cells to large differentiated ribbon/ tadpole shaped cells with abundant eosinophilic cytoplasm and cross-striations (rhabdomyoblasts) • IHC: positive for MyoD1, Myogenin A, Muscle Specific Actin or Desmin