What are molecular subtypes of DLBCL?

• The activated B-cell-like type (ABC) of DLBCL, NOS has an inferior outcome in response to standard therapies when compared to the germinal centre Bcell group (GCB) in most but not all clinical cohorts. • Gene expression profiling (GEP) is the gold standard for cell of origin (COO) determination. Studies comparing COO classification by gene expression compared to the Hans criteria have shown that GEP has superior performance in the prediction of overall survival