What are placental site trophoblastic tumor?

➢ Placental site trophoblastic tumors are derived from the placental site or intermediate trophoblast, a cell that has morphologic and functional features that overlap with those of trophoblasts and syncytiotrophoblasts. ➢ These uncommon diploid tumors, often XX in karyotype, typically arise a few months after pregnancy. ➢ Because intermediate trophoblasts do not produce hCG in large amounts, hCG concentrations are only slightly elevated. ➢ These tumors produce human placental lactogen. ➢ An indolent clinical course is typical, with a generally favorable outcome if the tumor is confined to the endomyometrium. ➢ Not as sensitive to chemotherapy as are other trophoblastic tumors, and the prognosis is poor when spread occurs beyond the uterus