How is tx of malignant duodenal tumors?

Pancreaticoduodenectomy is necessary for complete resection of most proximal duodenal malignancies. Surgery is indicated for localized disease; resect all adenocarcinomas and GIST. Medications: imatinib mesylate for GIST. Prognosis: after curative resection, overall 5-year survival rate is 30%; for adenocarcinoma, 5-year survival for stage I is 80%; stage III, 10–15%