What are mechanisms of action of naked Abs?

Effector functions : — Complement activation (CDC) — NK cell activation (ADCC) — Ex: Rituximab (Rituxan) : anti-CD20 approved in 1997 for NonHodgkin lymphoma Modulation of Ligand-Receptor interaction: — Agonist or antagonist effect on a receptor of cytokine, growth factor, hormone…. — Ex: Trastuzumab (Herceptin) anti-ErbB2 (or HER-2), approved in 1998 for treatment of breast cancer — Ex: Bavacizumab (avastin): anti-VEGF (vascular endothelial growth factor, treatment of colon cancer) approved in 2018